San Francisco de Macorís was at some point considered the third most important city in the Dominican Republic and is also the capital of the Duarte Province. It has had a very active role in the shaping of Dominican history, as it is known as one of, if not the most, politically active cities in the country. It is located in the northeast portion of the island, in the Cibao region. It is the home town of the author Hilma Contreras and home town of the world renowned playboy Porfirio Rubirosa.

The name San Francisco de Macorís comes from a fusion of the name of "la orden Franciscana" (a religious organization from Spain that had came to this territory during colonization) and the territoy's old name, which is Macorix.

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